Dynamics of Changes in Acetylcholinesterase Activity in the Brain and Bood of Rats During Pharmacological Correction of Seizures Caused by Carbamate

To simulate a convulsive syndrome, phenylcarbamate was administered intraperitoneally at dose of 1 mg/kg. Valproic acid aminoester (43 mg/kg), caramiphene (50 and diferidine (2 mg/kg) were investigated as potential anticonvulsant drugs. Blood brain tissue for the determination acetylcholinesterase (AСhE) taken 10, 30, 60 minutes, 6 24 hours after administration xenobiotic. In case poisoning with reversible inhibitors AChE accumulation acetylcholine in CNS synapses (due to inhibition activity), only initial manifestations activity are caused, other mechanisms not associated responsible processes further maintenance recurrence seizures.